BDBM26904 3-(2-aminoethyl)-8-[bis(2-chlorophenyl)methyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one::spiropiperidine analogue, 25

SMILES NCCN1CN(c2ccccc2)C2(CCN(CC2)C(c2ccccc2Cl)c2ccccc2Cl)C1=O

InChI Key InChIKey=WEJSFFXHSJTDMD-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 26904   

TargetDelta-type opioid receptor(Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26904(3-(2-aminoethyl)-8-[bis(2-chlorophenyl)methyl]-1-p...)
Affinity DataKi:  32nMAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26904(3-(2-aminoethyl)-8-[bis(2-chlorophenyl)methyl]-1-p...)
Affinity DataKi:  47.8nM ΔG°:  -9.88kcal/molepH: 7.4 T: 2°CAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26904(3-(2-aminoethyl)-8-[bis(2-chlorophenyl)methyl]-1-p...)
Affinity DataKi:  852nMAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM26904(3-(2-aminoethyl)-8-[bis(2-chlorophenyl)methyl]-1-p...)
Affinity DataKi:  886nMAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed