Found 13 hits for monomerid = 2691 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
cAMP-Dependent Protein Kinase (PKA)
(Bos taurus (bovine)) | BDBM2691
 (3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-...)Show SMILES NCCCn1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc12 Show InChI InChI=1S/C23H20N4O2/c24-10-5-11-27-13-17(15-7-2-4-9-19(15)27)21-20(22(28)26-23(21)29)16-12-25-18-8-3-1-6-14(16)18/h1-4,6-9,12-13,25H,5,10-11,24H2,(H,26,28,29) | PDB
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoires Glaxo
| Assay Description The activity of PKC, activated by phosphatidylserine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich hi... |
J Biol Chem 266: 15771-81 (1991)
Article DOI: 10.1021/jm0508282 BindingDB Entry DOI: 10.7270/Q2FF3QJ4 |
More data for this Ligand-Target Pair | |
cAMP-Dependent Protein Kinase (PKA)
(Rattus norvegicus (rat)) | BDBM2691
 (3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-...)Show SMILES NCCCn1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc12 Show InChI InChI=1S/C23H20N4O2/c24-10-5-11-27-13-17(15-7-2-4-9-19(15)27)21-20(22(28)26-23(21)29)16-12-25-18-8-3-1-6-14(16)18/h1-4,6-9,12-13,25H,5,10-11,24H2,(H,26,28,29) | PDB MMDB
Reactome pathway
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| Article PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoires Glaxo
| Assay Description The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone. |
J Biol Chem 266: 15771-81 (1991)
Article DOI: 10.1021/jm0508282 BindingDB Entry DOI: 10.7270/Q2FF3QJ4 |
More data for this Ligand-Target Pair | |
Phosphorylase Kinase
(Oryctolagus cuniculus (rabbit)) | BDBM2691
 (3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-...)Show SMILES NCCCn1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc12 Show InChI InChI=1S/C23H20N4O2/c24-10-5-11-27-13-17(15-7-2-4-9-19(15)27)21-20(22(28)26-23(21)29)16-12-25-18-8-3-1-6-14(16)18/h1-4,6-9,12-13,25H,5,10-11,24H2,(H,26,28,29) | UniProtKB/SwissProt
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| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoires Glaxo
| Assay Description The activity of PK is measured by its ability to transfer from [gamma-32P]ATP to phosphorylase b. |
J Biol Chem 266: 15771-81 (1991)
Article DOI: 10.1021/jm0508282 BindingDB Entry DOI: 10.7270/Q2FF3QJ4 |
More data for this Ligand-Target Pair | |
3-phosphoinositide-dependent protein kinase 1 (51-359)
(Homo sapiens (Human)) | BDBM2691
 (3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-...)Show SMILES NCCCn1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc12 Show InChI InChI=1S/C23H20N4O2/c24-10-5-11-27-13-17(15-7-2-4-9-19(15)27)21-20(22(28)26-23(21)29)16-12-25-18-8-3-1-6-14(16)18/h1-4,6-9,12-13,25H,5,10-11,24H2,(H,26,28,29) | PDB
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| n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | 7.5 | 30 |
University of Dundee
| Assay Description In vitro PDK1 assay using purified enzyme, was incubated with substrate PDKtide, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P inco... |
Structure 12: 215-26 (2004)
Article DOI: 10.1016/j.str.2004.01.005 BindingDB Entry DOI: 10.7270/Q2SJ1HV2 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Mutant (V143T)
(Homo sapiens (Human)) | BDBM2691
 (3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-...)Show SMILES NCCCn1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc12 Show InChI InChI=1S/C23H20N4O2/c24-10-5-11-27-13-17(15-7-2-4-9-19(15)27)21-20(22(28)26-23(21)29)16-12-25-18-8-3-1-6-14(16)18/h1-4,6-9,12-13,25H,5,10-11,24H2,(H,26,28,29) | PDB MMDB
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| MMDB PDB Article PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | 7.5 | 30 |
University of Dundee
| Assay Description In vitro PDK1 assay using purified enzyme, was incubated with substrate PDKtide, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P inco... |
Structure 12: 215-26 (2004)
Article DOI: 10.1016/j.str.2004.01.005 BindingDB Entry DOI: 10.7270/Q2SJ1HV2 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Mutant (L159M)
(Homo sapiens (Human)) | BDBM2691
 (3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-...)Show SMILES NCCCn1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc12 Show InChI InChI=1S/C23H20N4O2/c24-10-5-11-27-13-17(15-7-2-4-9-19(15)27)21-20(22(28)26-23(21)29)16-12-25-18-8-3-1-6-14(16)18/h1-4,6-9,12-13,25H,5,10-11,24H2,(H,26,28,29) | PDB MMDB
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| MMDB PDB Article PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | 7.5 | 30 |
University of Dundee
| Assay Description In vitro PDK1 assay using purified enzyme, was incubated with substrate PDKtide, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P inco... |
Structure 12: 215-26 (2004)
Article DOI: 10.1016/j.str.2004.01.005 BindingDB Entry DOI: 10.7270/Q2SJ1HV2 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Calcium/calmodulin-dependent protein kinase type II subunit delta
(Homo sapiens (Human)) | BDBM2691
 (3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-...)Show SMILES NCCCn1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc12 Show InChI InChI=1S/C23H20N4O2/c24-10-5-11-27-13-17(15-7-2-4-9-19(15)27)21-20(22(28)26-23(21)29)16-12-25-18-8-3-1-6-14(16)18/h1-4,6-9,12-13,25H,5,10-11,24H2,(H,26,28,29) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
Scios Inc
Curated by ChEMBL
| Assay Description Inhibition of CaMK2delta |
Bioorg Med Chem Lett 18: 2399-403 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.057 BindingDB Entry DOI: 10.7270/Q2M61M4W |
More data for this Ligand-Target Pair | |
3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Mutant (E166D)
(Homo sapiens (Human)) | BDBM2691
 (3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-...)Show SMILES NCCCn1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc12 Show InChI InChI=1S/C23H20N4O2/c24-10-5-11-27-13-17(15-7-2-4-9-19(15)27)21-20(22(28)26-23(21)29)16-12-25-18-8-3-1-6-14(16)18/h1-4,6-9,12-13,25H,5,10-11,24H2,(H,26,28,29) | PDB MMDB
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| MMDB PDB Article PubMed
| n/a | n/a | 5.70E+3 | n/a | n/a | n/a | n/a | 7.5 | 30 |
University of Dundee
| Assay Description In vitro PDK1 assay using purified enzyme, was incubated with substrate PDKtide, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P inco... |
Structure 12: 215-26 (2004)
Article DOI: 10.1016/j.str.2004.01.005 BindingDB Entry DOI: 10.7270/Q2SJ1HV2 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Mutant (T222A)
(Homo sapiens (Human)) | BDBM2691
 (3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-...)Show SMILES NCCCn1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc12 Show InChI InChI=1S/C23H20N4O2/c24-10-5-11-27-13-17(15-7-2-4-9-19(15)27)21-20(22(28)26-23(21)29)16-12-25-18-8-3-1-6-14(16)18/h1-4,6-9,12-13,25H,5,10-11,24H2,(H,26,28,29) | PDB MMDB
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| MMDB PDB Article PubMed
| n/a | n/a | 3.80E+3 | n/a | n/a | n/a | n/a | 7.5 | 30 |
University of Dundee
| Assay Description In vitro PDK1 assay using purified enzyme, was incubated with substrate PDKtide, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P inco... |
Structure 12: 215-26 (2004)
Article DOI: 10.1016/j.str.2004.01.005 BindingDB Entry DOI: 10.7270/Q2SJ1HV2 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Mutant (V143T/T222A)
(Homo sapiens (Human)) | BDBM2691
 (3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-...)Show SMILES NCCCn1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc12 Show InChI InChI=1S/C23H20N4O2/c24-10-5-11-27-13-17(15-7-2-4-9-19(15)27)21-20(22(28)26-23(21)29)16-12-25-18-8-3-1-6-14(16)18/h1-4,6-9,12-13,25H,5,10-11,24H2,(H,26,28,29) | PDB MMDB
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| MMDB PDB Article PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | 7.5 | 30 |
University of Dundee
| Assay Description In vitro PDK1 assay using purified enzyme, was incubated with substrate PDKtide, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P inco... |
Structure 12: 215-26 (2004)
Article DOI: 10.1016/j.str.2004.01.005 BindingDB Entry DOI: 10.7270/Q2SJ1HV2 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Calcium/calmodulin-dependent protein kinase type II subunit delta
(Homo sapiens (Human)) | BDBM2691
 (3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-...)Show SMILES NCCCn1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc12 Show InChI InChI=1S/C23H20N4O2/c24-10-5-11-27-13-17(15-7-2-4-9-19(15)27)21-20(22(28)26-23(21)29)16-12-25-18-8-3-1-6-14(16)18/h1-4,6-9,12-13,25H,5,10-11,24H2,(H,26,28,29) | PDB
Reactome pathway KEGG
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Patents
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| Article PubMed
| n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
Scios Inc
Curated by ChEMBL
| Assay Description Inhibition of CaMK2delta |
Bioorg Med Chem Lett 18: 2390-4 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.059 BindingDB Entry DOI: 10.7270/Q27W6D2W |
More data for this Ligand-Target Pair | |
Calcium/calmodulin-dependent protein kinase type II subunit delta
(Homo sapiens (Human)) | BDBM2691
 (3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-...)Show SMILES NCCCn1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc12 Show InChI InChI=1S/C23H20N4O2/c24-10-5-11-27-13-17(15-7-2-4-9-19(15)27)21-20(22(28)26-23(21)29)16-12-25-18-8-3-1-6-14(16)18/h1-4,6-9,12-13,25H,5,10-11,24H2,(H,26,28,29) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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CHEBI DrugBank MMDB PC cid PC sid PDB UniChem
Patents
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| Article PubMed
| n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
Scios Inc
Curated by ChEMBL
| Assay Description Inhibition of CaMK2delta |
Bioorg Med Chem Lett 18: 2395-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.058 BindingDB Entry DOI: 10.7270/Q2QZ2BVW |
More data for this Ligand-Target Pair | |
3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Mutant (A162V)
(Homo sapiens (Human)) | BDBM2691
 (3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-...)Show SMILES NCCCn1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc12 Show InChI InChI=1S/C23H20N4O2/c24-10-5-11-27-13-17(15-7-2-4-9-19(15)27)21-20(22(28)26-23(21)29)16-12-25-18-8-3-1-6-14(16)18/h1-4,6-9,12-13,25H,5,10-11,24H2,(H,26,28,29) | PDB MMDB
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| n/a | n/a | 3.40E+3 | n/a | n/a | n/a | n/a | 7.5 | 30 |
University of Dundee
| Assay Description In vitro PDK1 assay using purified enzyme, was incubated with substrate PDKtide, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P inco... |
Structure 12: 215-26 (2004)
Article DOI: 10.1016/j.str.2004.01.005 BindingDB Entry DOI: 10.7270/Q2SJ1HV2 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |