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BDBM269263 US10071086, Compound 11

SMILES: CN1CCN(CC1)c1cc(F)cc(c1)-c1cncc2[nH]c(nc12)-c1n[nH]c2ncc(cc12)-c1cccnc1

InChI Key: InChIKey=ZHCLGSSJTZSCHA-BYCLXTJYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 269263   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Beta-catenin-interacting protein 1


()
BDBM269263
PNG
(US10071086, Compound 11)
Show SMILES CN1CCN(CC1)c1cc(F)cc(c1)-c1cncc2[nH]c(nc12)-c1n[nH]c2ncc(cc12)-c1cccnc1
Show InChI InChI=1S/C28H22FN9/c1-37-5-7-38(8-6-37)21-10-18(9-20(29)12-21)23-15-31-16-24-25(23)34-28(33-24)26-22-11-19(14-32-27(22)36-35-26)17-3-2-4-30-13-17/h2-4,9-16H,5-8H2,1H3/b28-26+
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 210n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Compounds of Formulas (I) or (II) were screened in a β-catenin-based reporter assay in a transformed human bronchial epithelial cell line (NL-20...


US Patent US10071086 (2018)

More data for this
Ligand-Target Pair
Adenomatous polyposis coli protein


(Homo sapiens (human))
BDBM269263
PNG
(US10071086, Compound 11)
Show SMILES CN1CCN(CC1)c1cc(F)cc(c1)-c1cncc2[nH]c(nc12)-c1n[nH]c2ncc(cc12)-c1cccnc1
Show InChI InChI=1S/C28H22FN9/c1-37-5-7-38(8-6-37)21-10-18(9-20(29)12-21)23-15-31-16-24-25(23)34-28(33-24)26-22-11-19(14-32-27(22)36-35-26)17-3-2-4-30-13-17/h2-4,9-16H,5-8H2,1H3/b28-26+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 99n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Reporter cell lines can be generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a...


US Patent US10071086 (2018)

More data for this
Ligand-Target Pair