BDBM27014 2-[(3S,13S,16S,17R,19S)-3-({[(1S)-1-cyclohexyl-2-cyclopropyl-2-oxoethyl]carbamoyl}amino)-18,18-dimethyl-2,15-dioxo-1,14-diazatricyclo[14.4.0.0^{17,19}]icosan-13-yl]-2-oxoacetamide::ketoamide derived macrocyclic inhibitor, 38
SMILES CC1(C)[C@H]2CN3[C@@H]([C@@H]12)C(=O)N[C@@H](CCCCCCCCC[C@H](NC(=O)N[C@@H](C1CCCCC1)C(=O)C1CC1)C3=O)C(=O)C(N)=O
InChI Key InChIKey=WRVODXMWQBCAPK-QCOJBMJGSA-N
Data 1 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 27014
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute
Schering-Plough Research Institute
Affinity DataKi: 11nM ΔG°: -11.0kcal/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair