BDBM270542 2-(2-(2-(4-acryloyl-3,4- dihydro-2H-benzo[b][1,4] oxazin-6-ylamino)-5- chloropyrimidin-4- ylamino)phenyl)-N,N- dimethyl-2-oxoacetamide::US10059688, Example 87::US9783524, Example 87

SMILES CN(C)C(=O)C(=O)c1ccccc1Nc1nc(Nc2ccc3OCCN(C(=O)C=C)c3c2)ncc1Cl

InChI Key InChIKey=KXPICMSXZCNILY-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 270542   

TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM270542(2-(2-(2-(4-acryloyl-3,4- dihydro-2H-benzo[b][1,4] ...)
Affinity DataIC50:  15nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [L858R](Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM270542(2-(2-(2-(4-acryloyl-3,4- dihydro-2H-benzo[b][1,4] ...)
Affinity DataIC50:  225nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M](Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM270542(2-(2-(2-(4-acryloyl-3,4- dihydro-2H-benzo[b][1,4] ...)
Affinity DataIC50:  15nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM270542(2-(2-(2-(4-acryloyl-3,4- dihydro-2H-benzo[b][1,4] ...)
Affinity DataIC50:  21nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM270542(2-(2-(2-(4-acryloyl-3,4- dihydro-2H-benzo[b][1,4] ...)
Affinity DataIC50:  354nMAssay Description:Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4× Test Compound or 100 nL 100×...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM270542(2-(2-(2-(4-acryloyl-3,4- dihydro-2H-benzo[b][1,4] ...)
Affinity DataIC50:  15.1nMAssay Description:Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514) 1. 2.5 uL-4x Test Compound or 100 nL 100x plus 2.4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [L858R](Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM270542(2-(2-(2-(4-acryloyl-3,4- dihydro-2H-benzo[b][1,4] ...)
Affinity DataIC50:  225nMAssay Description:Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4× Test Compound or 100 nL 100×...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM270542(2-(2-(2-(4-acryloyl-3,4- dihydro-2H-benzo[b][1,4] ...)
Affinity DataIC50:  14.7nMAssay Description:Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4× Test Compound or 100 nL 100×...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM270542(2-(2-(2-(4-acryloyl-3,4- dihydro-2H-benzo[b][1,4] ...)
Affinity DataIC50:  21.3nMAssay Description:Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4× Test Compound or 100 nL 100×...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM270542(2-(2-(2-(4-acryloyl-3,4- dihydro-2H-benzo[b][1,4] ...)
Affinity DataIC50:  354nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent