BDBM270598 (S)-8-chloro-N4-(3- chloro-4- fluorophenyl)-N6- ((1-(1- ethylpiperidin-4-yl)- 1H-1,2,3-triazol-4- yl)(phenyl)methyl) quinazoline-4,6- diamine::US10059695, II-4::US10577352, Compound II-4

SMILES CCN1CCC(CC1)n1cc(nn1)[C@@H](Nc1cc(Cl)c2ncnc(Nc3ccc(F)c(Cl)c3)c2c1)c1ccccc1

InChI Key InChIKey=BGNGGPVTCBTSPQ-NDEPHWFRSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 270598   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM270598((S)-8-chloro-N4-(3- chloro-4- fluorophenyl)-N6- ((...)
Affinity DataIC50:  5.90nMpH: 7.0 T: 2°CAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM270598((S)-8-chloro-N4-(3- chloro-4- fluorophenyl)-N6- ((...)
Affinity DataEC50:  254nMAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM270598((S)-8-chloro-N4-(3- chloro-4- fluorophenyl)-N6- ((...)
Affinity DataIC50:  5.90nMAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM270598((S)-8-chloro-N4-(3- chloro-4- fluorophenyl)-N6- ((...)
Affinity DataEC50:  254nMpH: 7.0 T: 2°CAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent