BindingDB logo
myBDB logout

BDBM271285 US10059720, Example 100

SMILES: CCCCCCOc1ccnc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)c1

InChI Key: InChIKey=MMFCXDRDLLZSJY-PKOBYXMFSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 271285   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271285
PNG
(US10059720, Example 100)
Show SMILES CCCCCCOc1ccnc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)c1
Show InChI InChI=1S/C19H32N2O4/c1-4-5-6-7-10-25-16-8-9-21-15(12-16)13-19(24,18(22)23)17(20)11-14(2)3/h8-9,12,14,17,24H,4-7,10-11,13,20H2,1-3H3,(H,22,23)/t17-,19+/m0/s1
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271285
PNG
(US10059720, Example 100)
Show SMILES CCCCCCOc1ccnc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)c1
Show InChI InChI=1S/C19H32N2O4/c1-4-5-6-7-10-25-16-8-9-21-15(12-16)13-19(24,18(22)23)17(20)11-14(2)3/h8-9,12,14,17,24H,4-7,10-11,13,20H2,1-3H3,(H,22,23)/t17-,19+/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair