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BDBM271292 US10059720, Example 107

SMILES: C[C@H]1CC[C@@H](CC1)Oc1ccnc(C[C@@](O)([C@@H](N)CSC2CCC2)C(O)=O)c1

InChI Key: InChIKey=JRFXNSXTSGADOC-HUXIJIEQSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 271292   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leucyl-cystinyl aminopeptidase


(Homo sapiens)
BDBM271292
PNG
(US10059720, Example 107)
Show SMILES C[C@H]1CC[C@@H](CC1)Oc1ccnc(C[C@@](O)([C@@H](N)CSC2CCC2)C(O)=O)c1
Show InChI InChI=1S/C21H32N2O4S/c1-14-5-7-16(8-6-14)27-17-9-10-23-15(11-17)12-21(26,20(24)25)19(22)13-28-18-3-2-4-18/h9-11,14,16,18-19,26H,2-8,12-13,22H2,1H3,(H,24,25)/t14-,16-,19-,21+/m0/s1
PDB

NCI pathway
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KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 4.5n/an/an/an/an/an/a



Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271292
PNG
(US10059720, Example 107)
Show SMILES C[C@H]1CC[C@@H](CC1)Oc1ccnc(C[C@@](O)([C@@H](N)CSC2CCC2)C(O)=O)c1
Show InChI InChI=1S/C21H32N2O4S/c1-14-5-7-16(8-6-14)27-17-9-10-23-15(11-17)12-21(26,20(24)25)19(22)13-28-18-3-2-4-18/h9-11,14,16,18-19,26H,2-8,12-13,22H2,1H3,(H,24,25)/t14-,16-,19-,21+/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 1.70n/an/an/an/an/an/a



Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair