BDBM272777 US10065963, Example 177
SMILES CC1CN(CCS1(=O)=O)c1c(cc(Cl)c2c(ncn12)C#N)C(NC(=O)c1c(N)nn2cccnc12)C(F)(F)F
InChI Key InChIKey=MAGFOVVPVQPRDL-UHFFFAOYSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 272777
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Incyte
US Patent
Incyte
US Patent
Affinity DataIC50: <100nMpH: 6.7 T: 2°CAssay Description:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Incyte
US Patent
Incyte
US Patent
Affinity DataIC50: <1.00E+3nMAssay Description:To measure the Phosphorylated Ribosomal Protein S6 (RPS6) in cell lysates, THP-1 cells (Human Acute Monocytic Leukemia) are purchased from ATCC (Mana...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Incyte
US Patent
Incyte
US Patent
Affinity DataIC50: >2.00E+3nMpH: 6.7 T: 2°CAssay Description:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...More data for this Ligand-Target Pair