BDBM272777 US10065963, Example 177

SMILES CC1CN(CCS1(=O)=O)c1c(cc(Cl)c2c(ncn12)C#N)C(NC(=O)c1c(N)nn2cccnc12)C(F)(F)F

InChI Key InChIKey=MAGFOVVPVQPRDL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 272777   

LigandPNGBDBM272777(US10065963, Example 177)
Affinity DataIC50: <100nMpH: 6.7 T: 2°CAssay Description:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM272777(US10065963, Example 177)
Affinity DataIC50: <1.00E+3nMAssay Description:To measure the Phosphorylated Ribosomal Protein S6 (RPS6) in cell lysates, THP-1 cells (Human Acute Monocytic Leukemia) are purchased from ATCC (Mana...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM272777(US10065963, Example 177)
Affinity DataIC50: >2.00E+3nMpH: 6.7 T: 2°CAssay Description:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent