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BDBM273026 (R)-2-[5-(2-methylphenyl)-7-oxo-6,7-dihydro[1,3]thiazolo[5,4-d]pyrimidin-2-yl]pyrrolidine-1-carboxylic acid phenyl ester::US10065972, Example 69

SMILES: Cc1ccccc1-c1nc2sc(nc2c(=O)[nH]1)[C@H]1CCCN1C(=O)Oc1ccccc1

InChI Key: InChIKey=LVSLNKQNBLRQFN-QGZVFWFLSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 273026   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273026
PNG
((R)-2-[5-(2-methylphenyl)-7-oxo-6,7-dihydro[1,3]th...)
Show SMILES Cc1ccccc1-c1nc2sc(nc2c(=O)[nH]1)[C@H]1CCCN1C(=O)Oc1ccccc1
Show InChI InChI=1S/C23H20N4O3S/c1-14-8-5-6-11-16(14)19-25-20(28)18-22(26-19)31-21(24-18)17-12-7-13-27(17)23(29)30-15-9-3-2-4-10-15/h2-6,8-11,17H,7,12-13H2,1H3,(H,25,26,28)/t17-/m1/s1
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PC cid
PC sid
UniChem
US Patent
n/an/a 40n/an/an/an/a8.0n/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair