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BDBM273034 (R)-2-[5-(1-methylcyclopropoxy)-7-oxo-6,7-dihydro[1,3]thiazolo[5,4-d]pyrimidin-2-yl]pyrrolidine-1-carboxylic acid phenyl ester::US10065972, Example 104

SMILES: CC1(CC1)Oc1nc2sc(nc2c(=O)[nH]1)[C@H]1CCCN1C(=O)Oc1ccccc1

InChI Key: InChIKey=LTIXBAKFOWCXIN-CYBMUJFWSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 273034   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273034
PNG
((R)-2-[5-(1-methylcyclopropoxy)-7-oxo-6,7-dihydro[...)
Show SMILES CC1(CC1)Oc1nc2sc(nc2c(=O)[nH]1)[C@H]1CCCN1C(=O)Oc1ccccc1
Show InChI InChI=1S/C20H20N4O4S/c1-20(9-10-20)28-18-22-15(25)14-17(23-18)29-16(21-14)13-8-5-11-24(13)19(26)27-12-6-3-2-4-7-12/h2-4,6-7,13H,5,8-11H2,1H3,(H,22,23,25)/t13-/m1/s1
PDB
MMDB

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KEGG

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PC cid
PC sid
UniChem
n/an/a 73n/an/an/an/a8.0n/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair