BDBM273058 (R)-2-(7-fluoro-5-oxo-5H-[1,3,4]thiadiazolo[2,3-b]quinazolin-2-yl)pyrrolidine-1-carboxylic acid phenyl ester::US10065972, Example 155

SMILES Fc1ccc2nc3sc(nn3c(=O)c2c1)[C@H]1CCCN1C(=O)Oc1ccccc1

InChI Key InChIKey=FKYPBJHZDOCSNX-MRXNPFEDSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 273058   

TargetKynurenine/alpha-aminoadipate aminotransferase, mitochondrial(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

US Patent
LigandPNGBDBM273058((R)-2-(7-fluoro-5-oxo-5H-[1,3,4]thiadiazolo[2,3-b]...)
Affinity DataIC50:  320nMpH: 8.0Assay Description:The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent