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BDBM273078 (R)-N-(4-fluorobenzyl)-1-[6-methyl-5-(3-methyl-[1,2,4]oxadiazol-5-yl)-7-oxo-6,7-dihydro[1,3]thiazolo[5,4-d]pyrimidin-2-yl]pyrrolidine-2-carboxamide::US10065972, Example 213

SMILES: Cc1noc(n1)-c1nc2sc(nc2c(=O)n1C)N1CCC[C@@H]1C(=O)NCc1ccc(F)cc1

InChI Key: InChIKey=LAXPCHCSLLFEGE-CQSZACIVSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 273078   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273078
PNG
((R)-N-(4-fluorobenzyl)-1-[6-methyl-5-(3-methyl-[1,...)
Show SMILES Cc1noc(n1)-c1nc2sc(nc2c(=O)n1C)N1CCC[C@@H]1C(=O)NCc1ccc(F)cc1
Show InChI InChI=1S/C21H20FN7O3S/c1-11-24-18(32-27-11)16-26-19-15(20(31)28(16)2)25-21(33-19)29-9-3-4-14(29)17(30)23-10-12-5-7-13(22)8-6-12/h5-8,14H,3-4,9-10H2,1-2H3,(H,23,30)/t14-/m1/s1
PDB
MMDB

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UniProtKB/SwissProt

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UniChem
n/an/a 16n/an/an/an/a8.0n/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair