BDBM273107 (R)-1-(5-difluoromethyl-6-ethyl-7-oxo-6,7-dihydro-[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-N-[(2,5-dimethyl-2H-pyrazol-3-yl)methyl]pyrrolidine-2-carboxamide::US10065972, Example 313

SMILES CCn1c(nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1cc(C)nn1C)C(F)F

InChI Key InChIKey=ZXXUKVVHCGWSQT-GFCCVEGCSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 273107   

TargetKynurenine/alpha-aminoadipate aminotransferase, mitochondrial(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

US Patent
LigandPNGBDBM273107((R)-1-(5-difluoromethyl-6-ethyl-7-oxo-6,7-dihydro-...)
Affinity DataIC50:  1.10E+3nMpH: 8.0Assay Description:The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent