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BDBM273118 (R)-N-benzyl-1-[5-(2-fluorophenyl)-6-methyl-7-oxo-6,7-dihydro[1,3]thiazolo[5,4-d]pyrimidin-2-yl]pyrrolidine-2-carboxamide::US10065972, Example 345

SMILES: Cn1c(nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1ccccc1)-c1ccccc1F

InChI Key: InChIKey=UPUJNFPLJCMMDF-GOSISDBHSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 273118   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273118
PNG
((R)-N-benzyl-1-[5-(2-fluorophenyl)-6-methyl-7-oxo-...)
Show SMILES Cn1c(nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1ccccc1)-c1ccccc1F
Show InChI InChI=1S/C24H22FN5O2S/c1-29-20(16-10-5-6-11-17(16)25)28-22-19(23(29)32)27-24(33-22)30-13-7-12-18(30)21(31)26-14-15-8-3-2-4-9-15/h2-6,8-11,18H,7,12-14H2,1H3,(H,26,31)/t18-/m1/s1
PDB
MMDB

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UniChem
n/an/a 8.70n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair