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BDBM273124 (R)-N-benzyl-1-{5-[(R)-1-(N',N'-dimethylamino)ethyl]-6-methyl-7-oxo-6,7-dihydro[1,3]thiazolo[5,4-d]pyrimidin-2-yl}pyrrolidine-2-carboxamide::US10065972, Example 376

SMILES: C[C@@H](N(C)C)c1nc2sc(nc2c(=O)n1C)N1CCC[C@@H]1C(=O)NCc1ccccc1

InChI Key: InChIKey=ITONBABICOWVAW-GDBMZVCRSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 273124   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273124
PNG
((R)-N-benzyl-1-{5-[(R)-1-(N',N'-dimethylamino)ethy...)
Show SMILES C[C@@H](N(C)C)c1nc2sc(nc2c(=O)n1C)N1CCC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C22H28N6O2S/c1-14(26(2)3)18-25-20-17(21(30)27(18)4)24-22(31-20)28-12-8-11-16(28)19(29)23-13-15-9-6-5-7-10-15/h5-7,9-10,14,16H,8,11-13H2,1-4H3,(H,23,29)/t14-,16-/m1/s1
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n/an/a 14n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair