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BDBM273127 (R)-1-(5-acetyl-6-methyl-7-oxo-6,7-dihydro[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-N-benzylpyrrolidine-2-carboxamide::US10065972, Example 411

SMILES: CC(=O)c1nc2sc(nc2c(=O)n1C)N1CCC[C@@H]1C(=O)NCc1ccccc1

InChI Key: InChIKey=VOLDJDSZWFBGHC-CQSZACIVSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 273127   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273127
PNG
((R)-1-(5-acetyl-6-methyl-7-oxo-6,7-dihydro[1,3]thi...)
Show SMILES CC(=O)c1nc2sc(nc2c(=O)n1C)N1CCC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C20H21N5O3S/c1-12(26)16-23-18-15(19(28)24(16)2)22-20(29-18)25-10-6-9-14(25)17(27)21-11-13-7-4-3-5-8-13/h3-5,7-8,14H,6,9-11H2,1-2H3,(H,21,27)/t14-/m1/s1
PDB
MMDB

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KEGG

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PC cid
PC sid
UniChem
n/an/a 15n/an/an/an/a8.0n/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair