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BDBM273150 5-ethyl-6-methyl-2-[(R)-2-(2-phenylaminoacetyl)pyrrolidin-1-yl][1,3]thiazolo[5,4-d]pyrimidin-7(6H)-one::US10065972, Example 579

SMILES: CCc1nc2sc(nc2c(=O)n1C)N1CCC[C@@H]1C(=O)CNc1ccccc1

InChI Key: InChIKey=ANYNYCMITFVKDA-CQSZACIVSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 273150   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273150
PNG
(5-ethyl-6-methyl-2-[(R)-2-(2-phenylaminoacetyl)pyr...)
Show SMILES CCc1nc2sc(nc2c(=O)n1C)N1CCC[C@@H]1C(=O)CNc1ccccc1
Show InChI InChI=1S/C20H23N5O2S/c1-3-16-22-18-17(19(27)24(16)2)23-20(28-18)25-11-7-10-14(25)15(26)12-21-13-8-5-4-6-9-13/h4-6,8-9,14,21H,3,7,10-12H2,1-2H3/t14-/m1/s1
PDB
MMDB

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n/an/a 10n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair