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BDBM273159 (R)-N-benzyl-1-[5-(2-hydroxypropan-2-yl)-7-oxo-6,7-dihydro[1,3]thiazolo[5,4-d]pyrimidin-2-yl]pyrrolidine-2-carboxamide::US10065972, Example 606

SMILES: CC(C)(O)c1nc2sc(nc2c(=O)[nH]1)N1CCC[C@@H]1C(=O)NCc1ccccc1

InChI Key: InChIKey=YFHQVBUKOKTVHS-CYBMUJFWSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 273159   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273159
PNG
((R)-N-benzyl-1-[5-(2-hydroxypropan-2-yl)-7-oxo-6,7...)
Show SMILES CC(C)(O)c1nc2sc(nc2c(=O)[nH]1)N1CCC[C@@H]1C(=O)NCc1ccccc1
Show InChI InChI=1S/C20H23N5O3S/c1-20(2,28)18-23-16(27)14-17(24-18)29-19(22-14)25-10-6-9-13(25)15(26)21-11-12-7-4-3-5-8-12/h3-5,7-8,13,28H,6,9-11H2,1-2H3,(H,21,26)(H,23,24,27)/t13-/m1/s1
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PC cid
PC sid
UniChem
US Patent
n/an/a 7.60n/an/an/an/a8.0n/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair