BDBM274274 (R)-5-(5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-6-(4-chlorophenyl)-1,2-dimethyl-5,6-dihydropyrrolo[3,4-b]pyrrol-4(1H)-one::US9550796, Example 75

SMILES Cc1cc2C(=O)N([C@@H](c2n1C)c1ccc(Cl)cc1)c1cc(Cl)c(=O)n(C)c1

InChI Key InChIKey=ZBZCQXDDHPHITA-QGZVFWFLSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 274274   

TargetBromodomain-containing protein 4 [44-477](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM274274((R)-5-(5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-...)
Affinity DataIC50:  85.3nMpH: 7.5Assay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCREB-binding protein(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM274274((R)-5-(5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-...)
Affinity DataIC50:  790nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 3(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM274274((R)-5-(5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-...)
Affinity DataIC50:  53.3nMpH: 7.5Assay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 2 [60-463](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM274274((R)-5-(5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-...)
Affinity DataIC50:  135nMpH: 7.5Assay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent