BDBM274712 N-(6-(1-(2,2-difluoroethyl)-4-(4- fluorophenyl)-2-isopropyl-1H- imidazol-5-yl)imidazo[1,2-b] pyridazin-2-yl)-2-fluoroiso- nicotinamide::US9556179, Compound 287

SMILES CC(F)Cn1c(nc(c1-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1)-c1ccc(F)cc1)C(C)C

InChI Key InChIKey=QFBRSDLGGHKLNW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 274712   

TargetCasein kinase I isoform delta(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM274712(N-(6-(1-(2,2-difluoroethyl)-4-(4- fluorophenyl)-2-...)
Affinity DataIC50:  0.776nMpH: 7.4 T: 2°CAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCasein kinase I isoform epsilon(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM274712(N-(6-(1-(2,2-difluoroethyl)-4-(4- fluorophenyl)-2-...)
Affinity DataIC50:  9.17nMpH: 7.4 T: 2°CAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent