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BDBM274749 N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol-5-yl) imidazo[1,2-b]pyridazin-2- yl)-3-(pyridin-3-yl) benzamide::US9556179, Compound 325

SMILES: Cc1nc(c(-c2ccc3nc(NC(=O)c4cccc(c4)-c4cccnc4)cn3n2)n1C)-c1ccc(F)cc1

InChI Key: InChIKey=CEOSYJOMUHZUAF-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 274749   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM274749
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4cccc(c4)-c4cccnc4)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C29H22FN7O/c1-18-32-27(19-8-10-23(30)11-9-19)28(36(18)2)24-12-13-26-33-25(17-37(26)35-24)34-29(38)21-6-3-5-20(15-21)22-7-4-14-31-16-22/h3-17H,1-2H3,(H,34,38)
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.323n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I Epsilon


(Homo sapiens (Human))
BDBM274749
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4cccc(c4)-c4cccnc4)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C29H22FN7O/c1-18-32-27(19-8-10-23(30)11-9-19)28(36(18)2)24-12-13-26-33-25(17-37(26)35-24)34-29(38)21-6-3-5-20(15-21)22-7-4-14-31-16-22/h3-17H,1-2H3,(H,34,38)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.44n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair