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BDBM274752 N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol-5-yl) imidazo[1,2-b]pyridazin-2- yl)-5-quinolinecarboxamide::US9556179, Compound 327::US9556179, Compound 328

SMILES: Cc1nc(c(-c2ccc3nc(NC(=O)c4cccc5ncccc45)cn3n2)n1C)-c1ccc(F)cc1

InChI Key: InChIKey=XRLWUFAKRWKETA-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 274752   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Casein kinase I Epsilon


(Homo sapiens (Human))
BDBM274752
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4cccc5ncccc45)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C27H20FN7O/c1-16-30-25(17-8-10-18(28)11-9-17)26(34(16)2)22-12-13-24-31-23(15-35(24)33-22)32-27(36)20-5-3-7-21-19(20)6-4-14-29-21/h3-15H,1-2H3,(H,32,36)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 6.08n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM274752
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4cccc5ncccc45)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C27H20FN7O/c1-16-30-25(17-8-10-18(28)11-9-17)26(34(16)2)22-12-13-24-31-23(15-35(24)33-22)32-27(36)20-5-3-7-21-19(20)6-4-14-29-21/h3-15H,1-2H3,(H,32,36)
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.335n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I Epsilon


(Homo sapiens (Human))
BDBM274752
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4cccc5ncccc45)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C27H20FN7O/c1-16-30-25(17-8-10-18(28)11-9-17)26(34(16)2)22-12-13-24-31-23(15-35(24)33-22)32-27(36)20-5-3-7-21-19(20)6-4-14-29-21/h3-15H,1-2H3,(H,32,36)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.13n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair
Casein kinase I delta/epsilon


(Homo sapiens (Human))
BDBM274752
PNG
(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Show SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4cccc5ncccc45)cn3n2)n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C27H20FN7O/c1-16-30-25(17-8-10-18(28)11-9-17)26(34(16)2)22-12-13-24-31-23(15-35(24)33-22)32-27(36)20-5-3-7-21-19(20)6-4-14-29-21/h3-15H,1-2H3,(H,32,36)
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.676n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...


US Patent US9556179 (2017)

More data for this
Ligand-Target Pair