BDBM274777 1-acetyl-N-(6-(4-(4-fluoro- phenyl)-1,2-dimethyl-1H- imidazol-5-yl)imidazo[1,2-b] pyridazin-2-yl)-L-pro- linamide::US9556179, Compound 353::US9556179, Compound 363

SMILES CC(=O)N1CCCC1C(=O)Nc1cn2nc(ccc2n1)-c1c(nc(C)n1C)-c1ccc(F)cc1

InChI Key InChIKey=OGFALIANKHQUBE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 274777   

TargetCasein kinase I isoform epsilon(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM274777(1-acetyl-N-(6-(4-(4-fluoro- phenyl)-1,2-dimethyl-1...)
Affinity DataIC50:  74.2nMpH: 7.4 T: 2°CAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCasein kinase I isoform delta(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM274777(1-acetyl-N-(6-(4-(4-fluoro- phenyl)-1,2-dimethyl-1...)
Affinity DataIC50:  2.36nMpH: 7.4 T: 2°CAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCasein kinase I isoform epsilon(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM274777(1-acetyl-N-(6-(4-(4-fluoro- phenyl)-1,2-dimethyl-1...)
Affinity DataIC50:  26.2nMpH: 7.4 T: 2°CAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCasein kinase I isoform delta(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM274777(1-acetyl-N-(6-(4-(4-fluoro- phenyl)-1,2-dimethyl-1...)
Affinity DataIC50:  4.94nMpH: 7.4 T: 2°CAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent