BDBM275031 N2-(tert-butyl)-N8-(((trans)-2- phenylcyclopropyl)methyl)-5-(3- (trifluoromethyl)phenyl)-3,4- dihydroisoquinoline-2,8(1H)-dicarboxamide (mixture of 2 isomers)::US9877957, Example 69

SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(c1)C(F)(F)F)C(=O)NC[C@H]1C[C@@H]1c1ccccc1

InChI Key InChIKey=NKQMYDFZVQCTKV-AJTFRIOCSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 275031   

TargetDiacylglycerol O-acyltransferase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM275031(N2-(tert-butyl)-N8-(((trans)-2- phenylcyclopropyl)...)
Affinity DataIC50:  528nMpH: 7.0 T: 2°CAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent