BDBM27504 4-HQN::4-hydroxyquinazoline::CHEMBL266540::quinazolin-4-ol

SMILES O=c1[nH]cnc2ccccc12

InChI Key InChIKey=QMNUDYFKZYBWQX-UHFFFAOYSA-N

Data  6 KI  6 IC50  1 Kd

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 27504   

TargetCarbonic anhydrase 12(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM27504(4-HQN | 4-hydroxyquinazoline | CHEMBL266540 | quin...)
Affinity DataKi:  1.05E+4nMAssay Description:Inhibition of human recombinant carbonic anhydrase-12 preincubated for 6 hrs by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM27504(4-HQN | 4-hydroxyquinazoline | CHEMBL266540 | quin...)
Affinity DataKi:  1.57E+4nMAssay Description:Inhibition of human recombinant carbonic anhydrase-9 preincubated for 6 hrs by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM27504(4-HQN | 4-hydroxyquinazoline | CHEMBL266540 | quin...)
Affinity DataKi: >5.00E+5nMAssay Description:Inhibition of human recombinant carbonic anhydrase-1 preincubated for 6 hrs by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM27504(4-HQN | 4-hydroxyquinazoline | CHEMBL266540 | quin...)
Affinity DataKi: >5.00E+5nMAssay Description:Inhibition of human recombinant carbonic anhydrase-2 preincubated for 6 hrs by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM27504(4-HQN | 4-hydroxyquinazoline | CHEMBL266540 | quin...)
Affinity DataKi:  9.10E+5nMAssay Description:Inhibition of human N-terminal His6-tagged PDE10A2 catalytic domain expressed in Escherichia coli BL21(DE3) RIL cells using 3',5'-cGMP as substrate b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM27504(4-HQN | 4-hydroxyquinazoline | CHEMBL266540 | quin...)
Affinity DataKi:  9.10E+5nMAssay Description:Inhibition of human N-terminal His6-tagged PDE10A2 catalytic domain expressed in Escherichia coli BL21(DE3) RIL cells using 3',5'-cGMP as substrate b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM27504(4-HQN | 4-hydroxyquinazoline | CHEMBL266540 | quin...)
Affinity DataIC50:  5.75E+3nMAssay Description:Inhibition of PARP1 using TACS-Sapphire substrate for 30 mins by colorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM27504(4-HQN | 4-hydroxyquinazoline | CHEMBL266540 | quin...)
Affinity DataIC50:  3.45E+5nMAssay Description:Inhibition of His-tagged-truncated human PDK1 preincubated with substrate biotinylated-AKT3 for 30 mins measured after 3 hrs by Scintillation proximi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM27504(4-HQN | 4-hydroxyquinazoline | CHEMBL266540 | quin...)
Affinity DataIC50:  1.58E+4nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM27504(4-HQN | 4-hydroxyquinazoline | CHEMBL266540 | quin...)
Affinity DataIC50:  9.50E+3nMAssay Description:The compound was tested for poly(ADP-ribose)polymerase (PARP) inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Mus musculus (Mouse))
University Of Konstanz

LigandPNGBDBM27504(4-HQN | 4-hydroxyquinazoline | CHEMBL266540 | quin...)
Affinity DataIC50:  2.57E+4nMpH: 7.8 T: 2°CAssay Description:The enzymatic reaction of the recombinant PARP was quantified by SPA. Radioactivity incorporated from [3H]NAD+ into PAR, and then being captured by P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
St. John'S University

Curated by ChEMBL
LigandPNGBDBM27504(4-HQN | 4-hydroxyquinazoline | CHEMBL266540 | quin...)
Affinity DataIC50:  5.89E+3nMpH: 7.8 T: 2°CAssay Description:The enzymatic reaction of the recombinant PARP was quantified by SPA. Radioactivity incorporated from [3H]NAD+ into PAR, and then being captured by P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Mycobacterium tuberculosis)
Pontifical Catholic University Of Rio Grande Do Sul

Curated by ChEMBL
LigandPNGBDBM27504(4-HQN | 4-hydroxyquinazoline | CHEMBL266540 | quin...)
Affinity DataKd:  3.16E+5nMAssay Description:Binding affinity to Mycobacterium tuberculosis purine nucleoside phosphorylase by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed