BDBM27504 4-HQN::4-hydroxyquinazoline::CHEMBL266540::quinazolin-4-ol
SMILES O=c1[nH]cnc2ccccc12
InChI Key InChIKey=QMNUDYFKZYBWQX-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 13 hits for monomerid = 27504
Affinity DataKi: 1.05E+4nMAssay Description:Inhibition of human recombinant carbonic anhydrase-12 preincubated for 6 hrs by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.57E+4nMAssay Description:Inhibition of human recombinant carbonic anhydrase-9 preincubated for 6 hrs by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: >5.00E+5nMAssay Description:Inhibition of human recombinant carbonic anhydrase-1 preincubated for 6 hrs by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: >5.00E+5nMAssay Description:Inhibition of human recombinant carbonic anhydrase-2 preincubated for 6 hrs by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Vrije Universiteit Amsterdam
Curated by ChEMBL
Vrije Universiteit Amsterdam
Curated by ChEMBL
Affinity DataKi: 9.10E+5nMAssay Description:Inhibition of human N-terminal His6-tagged PDE10A2 catalytic domain expressed in Escherichia coli BL21(DE3) RIL cells using 3',5'-cGMP as substrate b...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Vrije Universiteit Amsterdam
Curated by ChEMBL
Vrije Universiteit Amsterdam
Curated by ChEMBL
Affinity DataKi: 9.10E+5nMAssay Description:Inhibition of human N-terminal His6-tagged PDE10A2 catalytic domain expressed in Escherichia coli BL21(DE3) RIL cells using 3',5'-cGMP as substrate b...More data for this Ligand-Target Pair
Affinity DataIC50: 5.75E+3nMAssay Description:Inhibition of PARP1 using TACS-Sapphire substrate for 30 mins by colorimetryMore data for this Ligand-Target Pair
Affinity DataIC50: 3.45E+5nMAssay Description:Inhibition of His-tagged-truncated human PDK1 preincubated with substrate biotinylated-AKT3 for 30 mins measured after 3 hrs by Scintillation proximi...More data for this Ligand-Target Pair
Affinity DataIC50: 1.58E+4nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
Affinity DataIC50: 9.50E+3nMAssay Description:The compound was tested for poly(ADP-ribose)polymerase (PARP) inhibitionMore data for this Ligand-Target Pair
Affinity DataIC50: 2.57E+4nMpH: 7.8 T: 2°CAssay Description:The enzymatic reaction of the recombinant PARP was quantified by SPA. Radioactivity incorporated from [3H]NAD+ into PAR, and then being captured by P...More data for this Ligand-Target Pair
Affinity DataIC50: 5.89E+3nMpH: 7.8 T: 2°CAssay Description:The enzymatic reaction of the recombinant PARP was quantified by SPA. Radioactivity incorporated from [3H]NAD+ into PAR, and then being captured by P...More data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Mycobacterium tuberculosis)
Pontifical Catholic University Of Rio Grande Do Sul
Curated by ChEMBL
Pontifical Catholic University Of Rio Grande Do Sul
Curated by ChEMBL
Affinity DataKd: 3.16E+5nMAssay Description:Binding affinity to Mycobacterium tuberculosis purine nucleoside phosphorylase by spectrophotometric analysisMore data for this Ligand-Target Pair