BDBM275230 1-[(3S,4R)-1-methyl-4-(5- methylthiophen-2- yl)pyrrolidin-3-yl]-3-[1-(2- methylpyridin-4-yl)-1H- pyrazolo[3,4-c]pyridin-5- yl)urea::US9884048, Example 124::US9884048, Example 188

SMILES CN1C[C@@H](NC(=O)Nc2cc3cnn(-c4ccnc(C)c4)c3cn2)[C@@H](C1)c1ccc(C)s1

InChI Key InChIKey=APQXGNCZLGMYPP-RTBURBONSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 275230   

TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM275230(1-[(3S,4R)-1-methyl-4-(5- methylthiophen-2- yl)pyr...)
Affinity DataIC50:  70nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM275230(1-[(3S,4R)-1-methyl-4-(5- methylthiophen-2- yl)pyr...)
Affinity DataIC50:  1.01nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent