BDBM275287 1-((3S,4R)1-methyl-4-phenyl- pyrrolidin-3-yl)-3-[1-(2-methyl- pyridin-4-yl)-1H-pyrazolo[3,4- c]pyridin-5-yl]urea::US9884048, Example 181

SMILES CN1CC(NC(=O)Nc2cc3cnn(-c4ccnc(C)c4)c3cn2)[C@@H](C1)c1ccccc1

InChI Key InChIKey=XGZZIQXUNIFRHE-BGERDNNASA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 275287   

TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM275287(1-((3S,4R)1-methyl-4-phenyl- pyrrolidin-3-yl)-3-[1...)
Affinity DataIC50:  0.980nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent