BDBM27533 4-(3-(1,4-diazepane-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one::4-[3-(1,4-diazepan-1-ylcarbonyl)-4-fluorobenzyl]phthalazin-1(2H)-one::4-[[3-(1,4-Diazepane-1-carbonyl)-4-fluorophenyl]methyl]-2Hphthalazin-1-one::4-{[3-(1,4-diazepan-1-ylcarbonyl)-4-fluorophenyl]methyl}-1,2-dihydrophthalazin-1-one::CHEMBL380648::Homopiperazine analogue, 14::KU-0058948
SMILES Fc1ccc(Cc2n[nH]c(=O)c3ccccc23)cc1C(=O)N1CCCNCC1
InChI Key InChIKey=HGEPGGJUGUMFHT-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 27533
Affinity DataIC50: 7nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibitory activity against PARP1More data for this Ligand-Target Pair
Affinity DataIC50: 3.40nMAssay Description:Inhibition of human PARP1More data for this Ligand-Target Pair
Affinity DataKd: 19nMAssay Description:Binding affinity to human PARP1 by isothermal titration colorimetryMore data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Institutet
Curated by ChEMBL
Institutet
Curated by ChEMBL
Affinity DataKd: 70nMAssay Description:Binding affinity to human PARP3 PARP domain by isothermal titration colorimetryMore data for this Ligand-Target Pair