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BDBM275767 US10071110, Compound CDV::US10071110, Compound Cidofovir(CDV)

SMILES: Nc1ccn(CC(CO)OCP(O)(O)=O)c(=O)n1

InChI Key: InChIKey=VWFCHDSQECPREK-UHFFFAOYSA-N

Data: 4 EC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 275767   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM275767
PNG
(US10071110, Compound CDV | US10071110, Compound Ci...)
Show SMILES Nc1ccn(CC(CO)OCP(O)(O)=O)c(=O)n1
Show InChI InChI=1S/C8H14N3O6P/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16)
PDB
MMDB

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UniProtKB/SwissProt

B.MOAD
DrugBank
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KEGG
PC cid
PC sid
PDB
UniChem
Article
US Patent
n/an/an/an/a 1.80E+3n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
The activity of cidofovir (CDV), cyclic cidofovir (cCDV), and 1-O-hexadecylpropanediol-3-cCDV (HDP-cCDV) were tested for antiviral activity in human ...


US Patent US10071110 (2018)


Article DOI: 10.1016/j.bmcl.2005.04.028
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM275767
PNG
(US10071110, Compound CDV | US10071110, Compound Ci...)
Show SMILES Nc1ccn(CC(CO)OCP(O)(O)=O)c(=O)n1
Show InChI InChI=1S/C8H14N3O6P/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
PDB
UniChem
Article
US Patent
n/an/an/an/a 460n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
Subconfluent human lung fibroblast cells (MRC-5, American Type Culture Collection, Rockville, Md.) in 24-well plates were treated with drugs diluted ...


US Patent US10071110 (2018)


Article DOI: 10.1016/j.bmcl.2005.04.028
More data for this
Ligand-Target Pair
Human herpes virus 5 capsid protein P40


(Human cytomegalovirus (strain AD169) (HHV-5) (Huma...)
BDBM275767
PNG
(US10071110, Compound CDV | US10071110, Compound Ci...)
Show SMILES Nc1ccn(CC(CO)OCP(O)(O)=O)c(=O)n1
Show InChI InChI=1S/C8H14N3O6P/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
PDB
UniChem
Article
US Patent
n/an/an/an/a 450n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
Antiviral assays for HCMV DNA were carried out by DNA hybridization as reported by Dankner, W. M., Scholl, D., Stanat, S. C., Martin, M., Souke, R. L...


US Patent US10071110 (2018)


Article DOI: 10.1016/j.bmcl.2005.04.028
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM275767
PNG
(US10071110, Compound CDV | US10071110, Compound Ci...)
Show SMILES Nc1ccn(CC(CO)OCP(O)(O)=O)c(=O)n1
Show InChI InChI=1S/C8H14N3O6P/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
PDB
UniChem
Article
US Patent
n/an/an/an/a 2.10E+3n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
The activity of cidofovir (CDV), cyclic cidofovir (cCDV), and 1-O-hexadecylpropanediol-3-cCDV (HDP-cCDV) were tested for antiviral activity in human ...


US Patent US10071110 (2018)


Article DOI: 10.1016/j.bmcl.2005.04.028
More data for this
Ligand-Target Pair