BDBM275867 US10071957, Example 86

SMILES COc1ncccc1-c1cc(ccc1Oc1cnc(OC(C)C)c(Cl)c1)C(=O)NS(=O)(=O)N1CCC1

InChI Key InChIKey=QSXHNPWOITXYHF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 275867   

TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM275867(US10071957, Example 86)
Affinity DataIC50:  22nMpH: 7.2Assay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM275867(US10071957, Example 86)
Affinity DataIC50:  11nMpH: 7.4 T: 2°CAssay Description:Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM275867(US10071957, Example 86)
Affinity DataIC50: >1.00E+4nMpH: 7.2Assay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent