BDBM27603 2-{4-[4-(2-{[4-(4-tert-butyl-2-chlorophenyl)-1H-pyrazol-3-yl]oxy}acetamido)-3-chlorophenyl]phenyl}acetic acid::pyrazolyl compound, 41

SMILES CC(C)(C)c1ccc(-c2cn[nH]c2OCC(=O)Nc2ccc(cc2Cl)-c2ccc(CC(O)=O)cc2)c(Cl)c1

InChI Key InChIKey=JLJKYEKBNAPOGV-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 27603   

TargetGag-Pol polyprotein [588-1027,K691N,Y769C]/[588-1147,K691N,Y769C](Human immunodeficiency virus type 1)
Boehringer Ingelheim (Canada)

LigandPNGBDBM27603(2-{4-[4-(2-{[4-(4-tert-butyl-2-chlorophenyl)-1H-py...)
Affinity DataIC50:  122nM EC50:  444nMAssay Description:IC50 values for wild-type and mutant RTs were obtained from a scintillation prox imity assay using poly rC/biotin-dG15 and 3H-dGTP. Each value repres...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027](Human immunodeficiency virus type 1 group M subtyp...)
Boehringer Ingelheim (Canada)

LigandPNGBDBM27603(2-{4-[4-(2-{[4-(4-tert-butyl-2-chlorophenyl)-1H-py...)
Affinity DataIC50: >3.30E+3nM EC50:  4.87E+3nMpH: 7.4 T: 2°CAssay Description:IC50 values for wild-type and mutant RTs were obtained from a scintillation proximity assay using poly rC/biotin-dG15 and 3H-dGTP. Each value represe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed