BDBM27641 1-(3-{[(2S)-2-aminopropanamido]methyl}phenyl)-N-[(2-methoxyphenyl)methyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::pyrazole scaffold, 1b

SMILES COc1ccccc1CNC(=O)c1cc(nn1-c1cccc(CNC(=O)[C@H](C)N)c1)C(F)(F)F

InChI Key InChIKey=KZCJXNWWNKSCHI-AWEZNQCLSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 27641   

TargetHistone-arginine methyltransferase CARM1(Mus musculus (mouse))
Methylgene

Curated by ChEMBL
LigandPNGBDBM27641(1-(3-{[(2S)-2-aminopropanamido]methyl}phenyl)-N-[(...)
Affinity DataIC50:  60nMAssay Description:Inhibition of N-terminal His-tagged mouse recombinant CARM1 expressed in Sf9 cells by microbeta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Mus musculus (mouse))
Methylgene

Curated by ChEMBL
LigandPNGBDBM27641(1-(3-{[(2S)-2-aminopropanamido]methyl}phenyl)-N-[(...)
Affinity DataIC50:  60nMpH: 9.0 T: 2°CAssay Description:Histone H3 is used as the substrate for CARM-1 enzyme, and the methylation is monitored using tritiated S-Adenosyl-Methionine (SAM) as a methyl donor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed