BDBM276796 8-({2,4-difluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-dioxido-1,2,4-thiadiazinan-5-yl]phenyl}amino)-1,7-naphthyridine-3-carbonitrile::US10071998, Example 11

SMILES CN1C(=N)N[C@@](C)(CS1(=O)=O)c1c(F)ccc(Nc2nccc3cc(cnc23)[N+]#[C-])c1F

InChI Key InChIKey=VPVXNJPVCHXXDB-FQEVSTJZSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 276796   

TargetBeta-secretase 2(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM276796(8-({2,4-difluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-...)
Affinity DataKi:  1.10nMpH: 5.0Assay Description:Inhibitor IC50s, at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEV...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM276796(8-({2,4-difluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-...)
Affinity DataKi:  2.10nMpH: 5.0Assay Description:The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM276796(8-({2,4-difluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-...)
Affinity DataKi:  2.10nMpH: 5.0Assay Description:The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent