BDBM27682 5-methyl-1,2,3,4-tetrahydroisoquinolin-1-one::CHEMBL125200::dihydroisoquinolinone, 1
SMILES Cc1cccc2C(=O)NCCc12
InChI Key InChIKey=RLLZPXDJYADIEU-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 27682
Affinity DataKi: 70nMAssay Description:Inhibition of human Poly (ADP-ribose) polymerase 1 enzymeMore data for this Ligand-Target Pair
Affinity DataIC50: 440nMAssay Description:Inhibition of the DNA repair Poly (ADP-ribose) polymerase 1, in permeabilised L1210 murine leukemia cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 420nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP10(Homo sapiens (Human))
Oregon Health And Science University
Curated by ChEMBL
Oregon Health And Science University
Curated by ChEMBL
Affinity DataIC50: 9.77E+3nMAssay Description:Inhibition of human PARP10 catalytic domain assessed as reduction in MARylation of His6-tagged SRPK2 substrate after 60 mins in presence of NAD+ by c...More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP10(Homo sapiens (Human))
Oregon Health And Science University
Curated by ChEMBL
Oregon Health And Science University
Curated by ChEMBL
Affinity DataIC50: 9.77E+3nMAssay Description:Inhibition of human PARP10 catalytic domain assessed as reduction in MARylation of His6-tagged SRPK2 substrate after 60 mins in presence of NAD+ by c...More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP11(Homo sapiens)
Oregon Health And Science University
Curated by ChEMBL
Oregon Health And Science University
Curated by ChEMBL
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of full length human His-SUMO-tagged PARP11 expressed in Escherichia coli BL21 assessed as reduction in MARylation of His6-tagged SRPK2 su...More data for this Ligand-Target Pair
Affinity DataIC50: 160nMpH: 8.0 T: 2°CAssay Description:To assess the inhibitory activity of novel inhibitors, the PARP-1 enzyme assay was carried out in reaction mixture consisting of Escherichia coli str...More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP11(Homo sapiens)
Oregon Health And Science University
Curated by ChEMBL
Oregon Health And Science University
Curated by ChEMBL
Affinity DataIC50: 2.14E+3nMAssay Description:Inhibition of full length human His-SUMO-tagged PARP11 expressed in Escherichia coli BL21 assessed as reduction in MARylation of His6-tagged SRPK2 su...More data for this Ligand-Target Pair