BDBM277327 US10072025, Example 2-5::tert-butyl 4-ethyl-4-(3-{[2- (oxan-4-yl)-1,1-dioxo-2,3- dihydro-1,2-benzothiazol- 5-yl] amino}-4-oxo- 1H,4H,5H-pyrazolo [4,3- c]pyridin-1-yl) piperidine- 1-carboxylate

SMILES CCC1(CCN(CC1)C(=O)OC(C)(C)C)n1nc(Nc2ccc3c(CN(C4CCOCC4)S3(=O)=O)c2)c2c1cc[nH]c2=O

InChI Key InChIKey=BWISHMDVCOHCAS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 277327   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM277327(US10072025, Example 2-5 | tert-butyl 4-ethyl-4-(3-...)
Affinity DataIC50:  0.600nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM277327(US10072025, Example 2-5 | tert-butyl 4-ethyl-4-(3-...)
Affinity DataIC50:  0.540nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent