BDBM277345 US10072025, Example 2-23::tert-butyl 4-ethyl-4-(4- oxo-3-(4-(piperidin-4- yl)phenylamino)-4,5- dihydropyrazolo[4,3- c]pyridin-1-yl) piperidine- 1-carboxylate

SMILES CCC1(CCN(CC1)C(=O)OC(C)(C)C)n1nc(Nc2ccc(cc2)C2CCNCC2)c2c1cc[nH]c2=O

InChI Key InChIKey=IOMXYGDCDPKFOJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 277345   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM277345(US10072025, Example 2-23 | tert-butyl 4-ethyl-4-(4...)
Affinity DataIC50:  1.92nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM277345(US10072025, Example 2-23 | tert-butyl 4-ethyl-4-(4...)
Affinity DataIC50:  1.13nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent