BDBM277347 US10072025, Example 2-25::tert-butyl 4-(3-(3- (difluoromethyl)-4- (thiomorpholine-4- carbonyl)phenyl amino)-4- oxo-4,5- dihydropyrazolo[4,3- c]pyridin-1-yl)-4- ethylpiperidine-1- carboxylate

SMILES CCC1(CCN(CC1)C(=O)OC(C)(C)C)n1nc(Nc2ccc(C(=O)N3CCSCC3)c(c2)C(F)F)c2c1cc[nH]c2=O

InChI Key InChIKey=UJYBRGPHKIPGOP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 277347   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM277347(US10072025, Example 2-25 | tert-butyl 4-(3-(3- (di...)
Affinity DataIC50:  2.80nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM277347(US10072025, Example 2-25 | tert-butyl 4-(3-(3- (di...)
Affinity DataIC50:  1.73nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent