BDBM277377 US10072025, Example 3-11::tert-butyl 4-ethyl-4-[3-({3- methyl-4-[(1- oxidothiomorpholin-4- yl)carbonyl]phenyl} amino)-4-oxo-4,5-dihydro- 1H-pyrazolo[4,3-c] pyridin-1-yl]piperidine-1- carboxylate

SMILES CCC1(CCN(CC1)C(=O)OC(C)(C)C)n1nc(Nc2ccc(C(=O)N3CCS(=O)CC3)c(C)c2)c2c1cc[nH]c2=O

InChI Key InChIKey=IJSLFYFMUJILFI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 277377   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM277377(US10072025, Example 3-11 | tert-butyl 4-ethyl-4-[3...)
Affinity DataIC50:  0.25nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM277377(US10072025, Example 3-11 | tert-butyl 4-ethyl-4-[3...)
Affinity DataIC50:  0.190nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent