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BDBM277725 3-({1-[2-(dimethylamino)pentyl]-5-fluoro-1H-indazol-3-yl}amino)pyridine-4-carboxylic acid::US10040779, Example 22

SMILES: CN(C)CCCCCn1nc(Nc2cnccc2C(O)=O)c2cc(F)ccc12

InChI Key: InChIKey=MQQZOGVKWBMWFV-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 277725   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM277725
PNG
(3-({1-[2-(dimethylamino)pentyl]-5-fluoro-1H-indazo...)
Show SMILES CN(C)CCCCCn1nc(Nc2cnccc2C(O)=O)c2cc(F)ccc12
Show InChI InChI=1S/C20H24FN5O2/c1-25(2)10-4-3-5-11-26-18-7-6-14(21)12-16(18)19(24-26)23-17-13-22-9-8-15(17)20(27)28/h6-9,12-13H,3-5,10-11H2,1-2H3,(H,23,24)(H,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
UniChem
n/an/a<0.100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US10040779 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM277725
PNG
(3-({1-[2-(dimethylamino)pentyl]-5-fluoro-1H-indazo...)
Show SMILES CN(C)CCCCCn1nc(Nc2cnccc2C(O)=O)c2cc(F)ccc12
Show InChI InChI=1S/C20H24FN5O2/c1-25(2)10-4-3-5-11-26-18-7-6-14(21)12-16(18)19(24-26)23-17-13-22-9-8-15(17)20(27)28/h6-9,12-13H,3-5,10-11H2,1-2H3,(H,23,24)(H,27,28)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/a 0.550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10040779 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM277725
PNG
(3-({1-[2-(dimethylamino)pentyl]-5-fluoro-1H-indazo...)
Show SMILES CN(C)CCCCCn1nc(Nc2cnccc2C(O)=O)c2cc(F)ccc12
Show InChI InChI=1S/C20H24FN5O2/c1-25(2)10-4-3-5-11-26-18-7-6-14(21)12-16(18)19(24-26)23-17-13-22-9-8-15(17)20(27)28/h6-9,12-13H,3-5,10-11H2,1-2H3,(H,23,24)(H,27,28)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/a<0.100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US10040779 (2018)

More data for this
Ligand-Target Pair