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BDBM277726 3-{[5-fluoro-1-(2,2,2-trifluoroethyl)-1H-indazol-3-yl]amino}-pyridine-4-carboxylic acid::US10040779, Example 23

SMILES: OC(=O)c1ccncc1Nc1nn(CC(F)(F)F)c2ccc(F)cc12

InChI Key: InChIKey=GPQRBFHFXGPAFQ-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 277726   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM277726
PNG
(3-{[5-fluoro-1-(2,2,2-trifluoroethyl)-1H-indazol-3...)
Show SMILES OC(=O)c1ccncc1Nc1nn(CC(F)(F)F)c2ccc(F)cc12
Show InChI InChI=1S/C15H10F4N4O2/c16-8-1-2-12-10(5-8)13(22-23(12)7-15(17,18)19)21-11-6-20-4-3-9(11)14(24)25/h1-6H,7H2,(H,21,22)(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
UniChem
n/an/a<0.100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US10040779 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C (KDM4C)


(Homo sapiens (Human))
BDBM277726
PNG
(3-{[5-fluoro-1-(2,2,2-trifluoroethyl)-1H-indazol-3...)
Show SMILES OC(=O)c1ccncc1Nc1nn(CC(F)(F)F)c2ccc(F)cc12
Show InChI InChI=1S/C15H10F4N4O2/c16-8-1-2-12-10(5-8)13(22-23(12)7-15(17,18)19)21-11-6-20-4-3-9(11)14(24)25/h1-6H,7H2,(H,21,22)(H,24,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/a 0.550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US10040779 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM277726
PNG
(3-{[5-fluoro-1-(2,2,2-trifluoroethyl)-1H-indazol-3...)
Show SMILES OC(=O)c1ccncc1Nc1nn(CC(F)(F)F)c2ccc(F)cc12
Show InChI InChI=1S/C15H10F4N4O2/c16-8-1-2-12-10(5-8)13(22-23(12)7-15(17,18)19)21-11-6-20-4-3-9(11)14(24)25/h1-6H,7H2,(H,21,22)(H,24,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/a<0.100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US10040779 (2018)

More data for this
Ligand-Target Pair