BDBM278417 (2S)-2-(dimethylamino)-2-(4-fluorophenyl)-N-[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]acetamide and (2R)-2-(dimethylamino)-2-(4-fluorophenyl)-N-[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]acetamide::US10040789, Example 2(a)::US10040789, Example 2(b)

SMILES CN(C)[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(F)cc1

InChI Key InChIKey=ZLUNIMIQWCCCHH-WBVHZDCISA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 278417   

TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM278417((2S)-2-(dimethylamino)-2-(4-fluorophenyl)-N-[5-[[(...)
Affinity DataIC50:  1.24E+3nMpH: 7.8 T: 2°CAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM278417((2S)-2-(dimethylamino)-2-(4-fluorophenyl)-N-[5-[[(...)
Affinity DataIC50:  74.6nMpH: 7.8 T: 2°CAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent