BDBM278540 (2E)-3-(3-Methyl-1-{[5-(3-methyloxetan-3-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid ::US10040791, Example 2

SMILES Cc1cn(C(=O)c2c(noc2C2(C)COC2)-c2c(Cl)cc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12

InChI Key InChIKey=HYWBLOXYWSBDNM-VOTSOKGWSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 278540   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132C](Homo sapiens (Human))
Daiichi Sankyo

US Patent
LigandPNGBDBM278540( (2E)-3-(3-Methyl-1-{[5-(3-methyloxetan-3-yl)-3-(2...)
Affinity DataIC50:  47nMpH: 7.5 T: 2°CAssay Description:The IDH1R132H protein and the IDH1R132C protein were prepared as follows: the IDH1R132H or IDH1R132C gene was integrated into a pET24b(+) vector (Nov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Daiichi Sankyo

US Patent
LigandPNGBDBM278540( (2E)-3-(3-Methyl-1-{[5-(3-methyloxetan-3-yl)-3-(2...)
Affinity DataIC50:  7nMpH: 7.5 T: 2°CAssay Description:The IDH1R132H protein and the IDH1R132C protein were prepared as follows: the IDH1R132H or IDH1R132C gene was integrated into a pET24b(+) vector (Nov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent