BDBM278673 (2E)-3-(1-{[3-(2,6-Dichlorophenyl)-5-(pyrrolidin-1-yl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 135

SMILES OC(=O)\C=C\c1cccc2n(ccc12)C(=O)c1c(onc1-c1c(Cl)cccc1Cl)N1CCCC1

InChI Key InChIKey=PNEPUQSOUVIVBT-MDZDMXLPSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 278673   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132C](Homo sapiens (Human))
Daiichi Sankyo

US Patent
LigandPNGBDBM278673( (2E)-3-(1-{[3-(2,6-Dichlorophenyl)-5-(pyrrolidin-...)
Affinity DataIC50:  122nMpH: 7.5 T: 2°CAssay Description:The IDH1R132H protein and the IDH1R132C protein were prepared as follows: the IDH1R132H or IDH1R132C gene was integrated into a pET24b(+) vector (Nov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Daiichi Sankyo

US Patent
LigandPNGBDBM278673( (2E)-3-(1-{[3-(2,6-Dichlorophenyl)-5-(pyrrolidin-...)
Affinity DataIC50:  14nMpH: 7.5 T: 2°CAssay Description:The IDH1R132H protein and the IDH1R132C protein were prepared as follows: the IDH1R132H or IDH1R132C gene was integrated into a pET24b(+) vector (Nov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent