BDBM278745 2-[(3R)- or (3S)-azepan- 3-ylamino]-N-[3- (difluoromethyl)-1- methyl-1H-pyrazol-4- yl]pyrrolo[1,2- b]pyridazine-7- carboxamide trifluoroacetate::US10040798, Example 42

SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(N[C@H]4CCCCNC4)nn23)c(n1)C(F)F

InChI Key InChIKey=ABBHNAUPFGLTCZ-YDALLXLXSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 278745   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM278745(2-[(3R)- or (3S)-azepan- 3-ylamino]-N-[3- (difluor...)
Affinity DataIC50:  0.300nMpH: 7.2Assay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent