BDBM278790 2-{[(1R,2R)-2-amino- 3,3-difluoro- cyclohexyl]amino}- N-(4- bromothiophen-3- yl)pyrrolo[1,2- b]pyridazine-7- carboxamide trifluoroacetate::US10040798, Example 88

SMILES OC(=O)C(F)(F)F.N[C@@H]1[C@@H](CCCC1(F)F)Nc1ccc2ccc(C(=O)Nc3cscc3Br)n2n1

InChI Key InChIKey=MKSUQNBCTYKDAF-VQZRABBESA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 278790   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM278790(2-{[(1R,2R)-2-amino- 3,3-difluoro- cyclohexyl]amin...)
Affinity DataIC50:  6.16E+3nMpH: 7.2Assay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent