BDBM278874 2-{[(1R,2S)-2-amino- cyclohexyl]amino}- N-(4-bromothiophen- 3-yl)thieno[2,3-b] pyrazine-7- carboxamide trifluoroacetate::US10040802, Example 53

SMILES OC(=O)C(F)(F)F.N[C@H]1CCCC[C@H]1Nc1cnc2scc(C(=O)Nc3cscc3Br)c2n1

InChI Key InChIKey=GVCILKLDPWJHIT-ZVWHLABXSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 278874   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM278874(2-{[(1R,2S)-2-amino- cyclohexyl]amino}- N-(4-bromo...)
Affinity DataIC50:  0.600nMpH: 7.2Assay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent