BDBM278885 N-(2-bromothiophen-3- yl)-2-[(1S,4S)- or (1R,4R)-2,5- diazabicylo[2.2.2]oct- 2-yl]thieno[2,3-b] pyrazine-7- carboxamide trifluoroacetate::US10040802, Example 64

SMILES OC(=O)C(F)(F)F.Brc1sccc1NC(=O)c1csc2ncc(nc12)N1C[C@H]2CC[C@@H]1CN2

InChI Key InChIKey=UERMRPORBBEXHH-DHTOPLTISA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 278885   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM278885(N-(2-bromothiophen-3- yl)-2-[(1S,4S)- or (1R,4R)-2...)
Affinity DataIC50:  767nMpH: 7.2Assay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent