BDBM27890 8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[2-(4-methylpiperazin-1-yl)ethyl]phenyl}amino)-5-oxo-5H,8H-pyrido[2,3-d]pyrimidine-6-carboxamide::Pyrido[2,3-d]pyrimidin-5-one, 17a

SMILES CN1CCN(CCc2ccc(Nc3ncc4c(n3)n(cc(C(N)=O)c4=O)-c3ccc4CCCc4c3)cc2)CC1

InChI Key InChIKey=KLHJDCUHOKZNOP-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 27890   

TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM27890(8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[2-(4-methylpi...)
Affinity DataIC50:  0.800nMpH: 7.5 T: 2°CAssay Description:FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM27890(8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[2-(4-methylpi...)
Affinity DataIC50:  1nMT: 2°CAssay Description:FLT-3 was assayed using a fluorescence polarization (FP) competition immunoassay that measured FLT-3 phosphorylation of polyGlu4Tyr. The reaction was...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM27890(8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[2-(4-methylpi...)
Affinity DataIC50: >500nMT: 2°CAssay Description:Axl was assayed using a fluorescence polarization (FP) competition immunoassay that measured Axl phosphorylation of polyGlu4Tyr. The reaction was ini...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM27890(8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[2-(4-methylpi...)
Affinity DataIC50:  8nMAssay Description:Inhibition of ATP-induced CSF1R autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM27890(8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[2-(4-methylpi...)
Affinity DataIC50:  20nMT: 2°CAssay Description:KIT was assayed using a fluorescence polarization (FP) competition immunoassay that measured KIT phosphorylation of polyGlu4Tyr. The reaction was ini...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM27890(8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[2-(4-methylpi...)
Affinity DataIC50: >4.20E+4nMT: 2°CAssay Description:IRKbeta was assayed using a fluorescence polarization (FP) competition immunoassay that measured IRKbeta phosphorylation of polyGlu4Tyr. The reaction...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor [440-796](Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM27890(8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[2-(4-methylpi...)
Affinity DataIC50:  170nMT: 2°CAssay Description:TrkA was assayed using a fluorescence polarization (FP) competition immunoassay that measured TrkA phosphorylation of polyGlu4Tyr. The reaction was i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed