BDBM278922 2-{[(1R,2S)-2- aminocyclohexyl]- amino}-N-[2- (difluoromethyl) phenyl]thieno- [2,3-b]- pyrazine-7- carboxamide trifluoroacetate::US10040802, Example 102

SMILES OC(=O)C(F)(F)F.N[C@H]1CCCC[C@H]1Nc1cnc2scc(C(=O)Nc3ccccc3C(F)F)c2n1

InChI Key InChIKey=RLQAVXNHLDKHGE-NQQJLSKUSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 278922   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM278922(2-{[(1R,2S)-2- aminocyclohexyl]- amino}-N-[2- (dif...)
Affinity DataIC50:  25nMpH: 7.2Assay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent